邱宪波

研究方向：

智能医学检测与创新仪器、微流控芯片与生化传感、光机电系统与POCT检测装置、生物医学信息处理与人工智能建模

Email: xbqiu@mail.buct.edu.cn

邱宪波，工学博士、教授、博士生导师，北京化工大学微流控芯片生物医学工程研究中心主任。美国宾夕法尼亚大学（University of Pennsylvania）博士后/研究助理（2006-2011），厦门大学副教授。从2002年至今，围绕“基础理论/方法创新-工程技术瓶颈突破-产业化应用”，主要从事：智能医学检测与创新仪器、微流控芯片与生化传感、光机电系统与POCT检测装置、生物医学信息处理与人工智能建模的基础及应用研究。在国际著名出版公司参与出版英文专著两章。在Sensors and Actuators B: Chemical、Lab on a Chip、Trends in Analytical Chemistry、Analytica Chimica Acta、Talanta等国内外知名期刊及会议发表论文100余篇，总引用2500余次。担任Nature Biomedical Engineering等期刊审稿人。申请或授权发明专利70项（国际专利2项，美国专利6项，韩国专利2项，印度专利1项，非洲专利1项）。作为技术负责人或核心人员，先后成功研发了96孔荧光定量实时PCR仪、便携式血糖仪、便携式心脏起搏器无线程控仪、免疫荧光检测仪、免疫胶体金检测仪、全自动一体化HIV快速诊断微流控芯片系统（免疫/核酸）、微流控对流PCR核酸检测系统、一体化核酸自动提取微流控芯片系统、CD4+T淋巴细胞计数检测微流控芯片系统、离心式微流控芯片及仪器、等温扩增检测微流控芯片及仪器等，多项研究成果实现了产业化应用。曾获得上海市科技进步三等奖、上海市高校学生“创造发明三枪杯奖”、中国过程控制学会中国过程控制年会张钟俊青年优秀论文二等奖、中国仪器仪表学会中国信息获取与处理年会优秀论文一等奖，北京化工大学2020年度重要科技进展等各类奖励。承担国家自然科学基金（面上）、国家科技重大专项子课题、北京化工大学双一流重大建设项目、中央高校基本科研业务费项目、北京化工大学-中日友好医院生物医学转化工程研究中心联合基金项目、及若干企事业单位合作课题。

地址/联系方式

北京市朝阳区北三环东路15号，北京化工大学计算机楼（东）210室

Email: xbqiu@mail.buct.edu.cn

教学课程Teaching courses

主要科研项目 Research Projects

主要成果、奖励Main achievements

代表性论文  Research Paper                                 

[1]Nan Wang, Xiaobin Dong, Yijie Zhou, Rui Zhu, Luyao Liu, Lulu Zhang and Xianbo Qiu*, A Low-Cost Handheld Centrifugal Microfluidic System for Multiplexed Visual Detection Based on Isothermal Amplification, Sensors, 2024, 24, 5028

[2]Luyao Liu, Lulu Zhang, Xueyu Zhang, Xiaobin Dong, Xiaodan Jiang, Xiaoqi Huang, Wei Li, Xiaoming Xie, Xianbo Qiu*, Analysis of cellular response to drugs with a microfluidic single-cell platform based on hyperspectral imaging, Analytica Chimica Acta, 2024, 1288, 342158

[3]Xiaobin Dong, Zhiqian Tang, Xiaodan Jiang, Qiang Fu, Donglin Xu, Lulu Zhang, Xianbo Qiu*, A highly sensitive, real-time centrifugal microfluidic chip for multiplexed detection based on isothermal amplification, Talanta, 2024, 268, 125319

[4]Qiang Fu, Yunping Tu, Lun Cheng, Lulu Zhang, Xianbo Qiu*, A fully-enclosed prototype ‘pen’ for rapid detection of SARS-CoV-2 based on RT-RPA with dipstick assay at point-of-care testing, Sensors and Actuators: B. Chemical, 2023, 383: 133531

[5] Guijun Miao, Xiaodan Jiang, Dianlong Yang, Qiang Fu, Lulu Zhang, Shengxiang Ge, Xiangzhong Ye, Ningshao Xia, Shizhi Qian, and Xianbo Qiu*, A Hand-Held, Real-Time, AI-Assisted Capillary Convection PCR System for Point-of-Care Diagnosis of African Swine Fever Virus, Sensors and Actuators B: Chemical, 2022, 358, 131476, https://doi.org/10.1016/j.snb.2022.131476

[6] Luyao Liu, Xiaobin Dong, Yunping Tu, Guijun Miao, Zhongping Zhang, Lulu Zhang, Zewen Wei, Duli Yu1, and Xianbo Qiu*, Methods and Platforms for Analysis of Nucleic Acids from Single-Cell Based on Microfluidics, Microfluidics and Nanofluidics, 2021, 25:87, https://doi.org/10.1007/s10404-021-02485-0

[7] Xiaobin Dong, Luyao Liu, Yunping Tu, Jing Zhang, Guijun Miao, Lulu Zhang, Shengxiang Ge, Ningshao Xia, Duli Yu, Xianbo Qiu*, Rapid PCR Powered by Microfluidics: A Quick Review Under the Background of COVID-19 Pandemic, Trends in Analytical Chemistry, 2021, 143, 116377

[8] Xianbo Qiu*, Huiqin Jiang, Xiaolei Zhang, Ke Li, Shengxiang Ge, Ningshao Xia, and Michael G. Mauk, Plasma Separator with Multifunctional Deformable Chamber Equipped with Porous Membrane for Point-of-Care Diagnostics, Analyst, 2020, 145, 6138 - 6147

[9] Guijun Miao, Lulu Zhang, Jing Zhang, Shengxiang Ge, Ningshao Xia, Shizhi Qian, Duli Yu, and Xianbo Qiu*, Free convective PCR: From principle study to commercial applications—A critical review, Analytica Chimica Acta, 2020, 1108, 177-197 (封面文章)

[10] Xianbo Qiu*, Shiyin Zhang, Fei Xiang, Di Wu, Meng Guo, Shengxiang Ge, Ke Li, Xiangzhong Ye, Ningshao Xia, and Shizhi Qian, Instrument-Free Point-of-Care Molecular Diagnosis of H1N1 Based on Microfluidic Convective PCR, Sensors and Actuators B: Chemical, 2017, 243, 738–744

[11] Huiqin Jiang, Di Wu, Liuwei Song, Quan Yuan, Shengxiang Ge, Xiaoping Min, Ningshao Xia, Shizhi Qian, Xianbo Qiu*, A Smartphone-Based Genotyping Method for Hepatitis B Virus at Point-of-Care Settings, SLAS Technology. 2017, 22(2), 122-129 (the 2018 SLAS Technology Ten: Translating Life Sciences Innovation, 入选SLAS2018十大热点文章, Jan. 24, 2018)

[12] Xianbo Qiu*, Liuwei Song, Shuo Yang, Meng Guo, Quan Yuan, Shengxiang Ge, Xiaoping Min, Ningshao Xia, A fast and low-cost genotyping method for hepatitis B virus based on pattern recognition in point-of-care settings, Scientific Reports, 2016, 6: 28274

[13] Xianbo Qiu, Changchun Liu, Michael G. Mauk, Robert W. Hart, Dafeng Chen, Jing Qiu, Terry Kientz, Jonathan Fiene, and Haim H. Bau*, A portable analyzer for pouch-actuated, immunoassay cassettes, Sensors and Actuators B: Chemical, 2011, 160(1), 1529-1535

[14] Changchun Liu, Michael G. Mauk, Robert Hart, Xianbo Qiu, and Haim H. Bau*, A self-heating cartridge for molecular diagnostics, Lab on a Chip, 2011, 11(16), 2686-2692

[15] Changchun Liu, Eran Geva, Michael Mauk, Xianbo Qiu, William R. Abrams, Daniel Malamud, Kelly Curtis, S. Michele Owen and Haim H. Bau*, An isothermal amplification reactor with an integrated isolation membrane for point-of-care detection of infectious diseases, Analyst, 2011, 136(10), 2069-2076

[16] Jitae Kim, Michael Mauk, Dafeng Chen, Xianbo Qiu, Jungkyu Kim, Bruce Gale and Haim H. Bau*, A PCR reactor with an integrated alumina membrane for nucleic acid isolation, Analyst, 2010, 135(9), 2408-2414

[17] Xianbo Qiu, Michael G. Mauk, Dafeng Chen, Changchun Liu and Haim H. Bau*, A large volume, portable, real-time PCR reactor, Lab on a Chip, 2010, 10(22), 3170–3177

[18] Dafeng Chen, Michael Mauk, Xianbo Qiu, Changchun Liu, Jitae Kim, Sudhir Ramprasad, Serge Ongagna, William R. Abrams, Daniel Malamud, Paul L. A. M. Corstjens and Haim H. Bau*, An integrated microfluidic cassette for isolation, amplification, and detection of nucleic acids, Biomedical Microdevices, 2010, 12(4), 705-719

[19] Xianbo Qiu, Jason A. Thompson, Zongyuan Chen, Changchun Liu, Dafeng Chen, Sudhir Ramprasad, Michael G. Mauk, Serge Ongagna, Cheryl Barber, William R. Abrams, Daniel Malamud, Paul L. A. M. Corstjens and Haim H. Bau*, Finger-actuated, self-contained immunoassay cassettes, Biomedical Microdevices, 2009, 11(6), 1175-1186

[20] Changchun Liu, Xianbo Qiu, Serge Ongagna, Dafeng Chen, Zongyuan Chen, William R. Abrams, Daniel Malamud, Paul L. A. M. Corstjens and Haim H. Bau*, A timer-actuated immunoassay cassette for detecting molecular markers in oral fluids, Lab on a Chip, 2009, 9(6), 768-776

专利、软件著作权

申请或授权发明专利70项（国际专利2项，美国专利6项，韩国专利2项，印度专利1项，非洲专利1项）；获批软件著作权10余项。

奖励

曾获得上海市科技进步三等奖、上海市发明协会上海市高校学生“创造发明三枪杯奖”、中国过程控制学会中国过程控制年会张钟俊青年优秀论文二等奖、中国仪器仪表学会中国信息获取与处理年会优秀论文一等奖、3rd Class Award of Conference Poster Contest, “Lab-on-a-chip for point-of-care nucleic acid based testing”, The Annual "Discovery to Commercialization Conference" of the Nanotechnology Institute, Philadelphia, USA, 2009、北京化工大学优秀班主任、北京化工大学2020年度重要科技进展等奖励。

研究成果Research Achievements