微系统与可穿戴医疗及生物传感技术创新团队

邱宪波，博士，教授

发布人：信息学院发布时间：2020-03-26浏览次数：754

邱宪波，工学博士，教授，博士生导师。2006年毕业于上海交通大学控制理论与控制工程专业，获工学博士学位，2006.12-2011.3，美国宾夕法尼亚大学（UPenn）博士后/研究助理。在生物医学工程领域，尤其是POCT（Point-of-Care Testing）现场快速检测领域，重点围绕：1）POCT核酸快速检测；2）POCT免疫检测；3）POCT集成微流控/纸基检测平台，开展“基础理论/方法创新-工程技术瓶颈突破-产品产业化应用”一体化交叉学科研究。自2016年，担任北京化工大学微流控芯片生物医学工程研究中心主任。担任中国仪器仪表学会微纳器件与系统技术分会理事。曾担任SCI期刊客座编辑，长期担任SCI期刊审稿人。多次在国际/国内重要学术会议作特邀学术报告。截止2020年3月，在Springer参与出版学术专著一章，在国内外主流期刊共发表60余篇学术论文（SCI论文：40余篇，论文总引用1200余次）；相关成果申请/授权发明专利近50余项（2项PCT国际发明专利，4项美国发明专利）。作为技术负责人或核心人员，先后成功研发了荧光定量实时PCR仪、便携式血糖仪、心脏起搏器无线程控仪、免疫荧光/胶体金检测仪、HIV核酸诊断集成微流控系统、微流控对流PCR扩增检测系统、核酸自动提取微流控系统、及多指标联合检测微流控系统等，其中多项成果成功实现产业化。主持科研项目包括：2项国家自然科学基金（面上项目）、1项国家科技重大专项子课题、1项福建省科学技术厅重大项目、1项北京化工大学双一流重大建设项目，2项中央高校基本科研业务费项目、1项北京化工大学-中日友好医院生物医学转化工程研究中心联合基金项目，及若干科研院所与企业的研究课题。曾获得2004年上海市科技进步三等奖、2003年上海市高校学生“创造发明三枪杯奖”、2005年中国过程控制年会张钟俊青年优秀论文二等奖、及2005年中国信息获取与处理年会优秀论文一等奖等奖励。通信地址：北京市朝阳区北三环东路15号北京化工大学信息学院210室。电子邮箱：xbqiu@mail.buct.edu.cn


主持科研项目 Research Projects

项目名称

项目来源

带核酸提取的一体化对流CPCR微流控核酸诊断方法研究

国家自然科学基金（面上）

科技部“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项，新型艾滋病检测系列产品及乙肝微量精准检测系列产品的研制，子课题：HIV快速检测仪器的研发

科技部重大专项（子课题）

基于微流控集成芯片的全自动CD4+T淋巴细胞计数HIV艾滋病现场检测方法研究

国家自然科学基金（面上）

单细胞微流控芯片精准分析诊断系统

北京化工大学双一流重大建设项目

微流控芯片快速检测技术开发

企业横向课题


主要论文Research Paper

  1. Guijun Miao, Lulu Zhang, Jing Zhang, Shengxiang Ge, Ningshao Xia, Shizhi Qian, Duli Yu, and Xianbo Qiu*, Free convective PCR: From principle study to commercial applications—A critical review, Analytica Chimica Acta, 2020, https://doi.org/10.1016/j.aca.2020.01.069

  2. Jung Il Shu, Oktay Baysal*, Shizhi Qian, Xianbo Qiu, Computational Design of a Single Heater Convective-PCR for Point-of-Care,Journal of Medical Devices,2019, 13(4): 041007 (10 pages)

  3. Xianbo Qiu*, Jung Il Shu, Oktay Baysal, Jie Wu, Shizhi Qian, Shengxiang Ge, Ke Li, Xiangzhong Ye, Ningshao Xia, and Duli Yu, Real-Time Capillary Convective PCR based on Horizontal Thermal Convection, Microfluidics and Nanofluidics, 2019, 23: 39

  4. Jung-Il Shu, Oktay Baysal*, Shizhi Qian, Xianbo Qiu, Fuhao Wang, Performance of convective polymerase chain reaction by doubling time, International Journal of Heat and Mass Transfer, 2019, 133, 1230–1239

  5. Xianbo Qiu*, Shuo Yang, Di Wu, Dong Wang, Shan Qiao, Shengxiang Ge, Ningshao Xia, Duli Yu, Shizhi Qian, Rapid enumeration of CD4 + T lymphocytes using an integrated microfluidic system based on Chemiluminescence image detection at point-of-care testing, Biomedical Microdevices, 2018, 20(15), https://doi.org/10.1007/s10544-018-0263-y

  6. Michael G Mauk*, Jinzhao Song, Changchun Liu and Xianbo Qiu, Pouch-Chip Immunoassays and Nucleic Acid Amplification Tests, Advanced Techniques in Biology & Medicine, 2017, 1572, 476-488

  7. Xianbo Qiu*, Junhui Zhang, Yichen Li, Chaomin Zhang, Dong Wang, Weiling Zhu, Fang Li, Shengxiang Ge, Ningshao Xia, Shizhi Qian, A bead-based microfluidic system for joint detection in TORCH screening at point-of-care testing, Microsystem Technologies, 2017, 24, 2007-2015

  8. Xianbo Qiu*, Junhui Zhang, Shisong Gong, Dong Wang, Shan Qiao, Shengxiang Ge, Ningshao Xia, Duli Yu, and Shizhi Qian, A Single-Bead-Based, Fully Integrated Microfluidic System for High-Throughput CD4+T Lymphocyte Enumeration, SLAS Technology, 2017, 23(2), 134-143

  9. Xianbo Qiu*, Shiyin Zhang, Lanju Mei, Di Wu, Qi Guo, Ke Li, Shengxiang Ge, Xiangzhong Ye, Ningshao Xia, and Michael G. Mauk, Characterization and ****ysis of real-time capillary convective PCR toward commercialization, Biomicrofluidics, 2017, 11(2): 024103

  10. Di Wu, Junhui Zhang, Feihai Xu, Xin Wen, Pengfei Li, Xiaolei Zhang, Shan Qiao, Shengxiang Ge, Ningshao Xia, Shizhi Qian, Xianbo Qiu*, A Paper-based Microfluidic Dot-ELISA System with Smartphone for the Detection of Influenza A, Microfluidics and Nanofluidics, 2017, 21: 43

  11. Xianbo Qiu*, Shiyin Zhang, Fei Xiang, Di Wu, Meng Guo, Shengxiang Ge, Ke Li, Xiangzhong Ye, Ningshao Xia, and Shizhi Qian, Instrument-Free Point-of-Care Molecular Diagnosis of H1N1 Based on Microfluidic Convective PCR, Sensors and Actuators B: Chemical, 2017, 243, 738–744

  12. Huiqin Jiang, Di Wu, Liuwei Song, Quan Yuan, Shengxiang Ge, Xiaoping Min, Ningshao Xia, Shizhi Qian, Xianbo Qiu*, A Smartphone-Based Genotyping Method for Hepatitis B Virus at Point-of-Care Settings, SLAS Technology. 2017, 22(2), 122-129 (the 2018 SLAS Technology Ten: Translating Life Sciences Innovation, 入选SLAS2018十大热点文章, Jan. 24, 2018)

  13. 牛亚男，阳勇良，宋浏伟，袁权，葛胜祥，闵小平，唐章宏，俞度立，邱宪波*，一种现场快速型HBV基因分型方法及装置，中国生物医学工程学报，2017，36(6)，764-768

  14. Xue Li, Yanan Niu, Yunyi Chen, Di Wu, Long Yi, Xianbo Qiu*, Microfluidic Paper-based Sample Concentration Using Ion Concentration Polarization with Smartphone Detection, Micromachines, 2016, 7(11), 199

  15. Xianbo Qiu*, Liuwei Song, Shuo Yang, Meng Guo, Quan Yuan, Shengxiang Ge, Xiaoping Min, Ningshao Xia, A fast and low-cost genotyping method for hepatitis B virus based on pattern recognition in point-of-care settings, Scientific Reports, 2016, 6: 28274

  16. Wei Li*, Lucheng Wu, Xianbo Qiu*, Qiong Ran and Xiaoming Xie, Parallel computation for blood cell classification in medical hyperspectral imagery, Measurement Science and Technology, 2016, 27(9): 095102

  17. Xianbo Qiu*, Shengxiang Ge, Pengfei Gao, Ke Li, Shuo Yang, Shiyin Zhang, Xiangzhong Ye, and Ningshao Xia, Shizhi Qian, A Smartphone-Based Point-of-Care Diagnosis of H1N1 with Microfluidic Convection PCR, Microsystem Technology, 2016, 23(7), 2951-2956;

  18. Xianbo Qiu*, Shengxiang Ge, Pengfei Gao, Ke Li, Yongliang Yang, Shiyin Zhang, Xiangzhong Ye, and Ningshao Xia, Shizhi Qian, A Low-Cost and Fast Real-Time PCR System Based on Capillary Convection, Journal of Laboratory Automation, 2016, 22(1), 13-17

  19. Xianbo Qiu* and Michael G. Mauk, An integrated, cellulose membrane-based PCR chamber, Microsystem Technologies, 2015, 21(4), 841-850

  20. 雷相阳，邱宪波*，葛胜祥，夏宁邵，陈兴，崔大付，基于微流控芯片的CD4+T淋巴细胞计数检测,化学进展, 2015, 27(7), 870-881

  21. Yongbin Gu, Yongliang Yang, Jing Zhang, ShengXiang Ge, Zhanghong Tang and Xianbo Qiu*, Point-of-care test for C-reactive protein by a fluorescence-based lateral flow immunoassay, Instrumentation Science and Technology, 2014, 42(6), 635-645

  22. Changchun Liu, Michael G. Mauk, Robert Hart, Xianbo Qiu, and Haim H. Bau*, A self-heating cartridge for molecular diagnostics, Lab on a Chip, 2011, 11(16), 2686-2692

  23. Xianbo Qiu, Changchun Liu, Michael G. Mauk, Robert W. Hart, Dafeng Chen, Jing Qiu, Terry Kientz, Jonathan Fiene, and Haim H. Bau*, A portable ****yzer for pouch-actuated, immunoassay cassettes, Sensors and Actuators B: Chemical, 2011, 160(1), 1529-1535

  24. Xianbo Qiu, Dafeng Chen, Changchun Liu, Michael G. Mauk, Terry Kientz and Haim H. Bau*, A portable, integrated ****yzer for microfluidic - based molecular ****ysis, Biomedical Microdevices, 2011, 13(5), 809-817

  25. Hart, R. W., M. G. Mauk, C. Liu, X. Qiu, J. A. Thompson, D. Chen, D. Malamud, W. R. Abrams, and H. H. Bau*, Point of care oral-based diagnostics, Oral Diseases, 2011, 17(8), 745-752

  26. Changchun Liu, Eran Geva, Michael Mauk, Xianbo Qiu, William R. Abrams, Daniel Malamud, Kelly Curtis, S. Michele Owen and Haim H. Bau*, An isothermal amplification reactor with an integrated isolation membrane for point-of-care detection of infectious diseases, Analyst, 2011, 136(10), 2069-2076

  27. Xianbo Qiu, Michael G. Mauk, Dafeng Chen, Changchun Liu and Haim H. Bau*, A large volume, portable, real-time PCR reactor, Lab on a Chip, 2010, 10(22), 3170–3177

  28. Dafeng Chen, Michael Mauk, Xianbo Qiu, Changchun Liu, Jitae Kim, Sudhir Ramprasad, Serge Ongagna, William R. Abrams, Daniel Malamud, Paul L. A. M. Corstjens and Haim H. Bau*, An integrated microfluidic cassette for isolation, amplification, and detection of nucleic acids, Biomedical Microdevices, 2010, 12(4), 705-719

  29. Jitae Kim, Michael Mauk, Dafeng Chen, Xianbo Qiu, Jungkyu Kim, Bruce Gale and Haim H. Bau*, A PCR reactor with an integrated alumina membrane for nucleic acid isolation, Analyst, 2010, 135(9), 2408-2414

  30. Xianbo Qiu, Jason A. Thompson, Zongyuan Chen, Changchun Liu, Dafeng Chen, Sudhir Ramprasad, Michael G. Mauk, Serge Ongagna, Cheryl Barber, William R. Abrams, Daniel Malamud, Paul L. A. M. Corstjens and Haim H. Bau*, Finger-actuated, self-contained immunoassay cassettes, Biomedical Microdevices, 2009, 11(6), 1175-1186

  31. Changchun Liu, Xianbo Qiu, Serge Ongagna, Dafeng Chen, Zongyuan Chen, William R. Abrams, Daniel Malamud, Paul L. A. M. Corstjens and Haim H. Bau*, A timer-actuated immunoassay cassette for detecting molecular markers in oral fluids, Lab on a Chip, 2009, 9(6), 768-776

  32. Xianbo Qiu and Jingqi Yuan*, Hybrid control strategy for thermal cycling of PCR based on microcomputer, Instrumentation Science & Technology, 2007, 35(1), 41-52

  33. Xianbo Qiu, Jingqi Yuan* and Zhifeng Wang, Feedforward variable structural PID for temperature control of PCR, Chinese Journal of Chemical Engineering, 2006, 14(2), 200-206


研究成果Research Achievements